CHEM-4544: Medicinal Chemistry Capstone Laboratory
Description: Laboratory experience tracing a standard pathway that potential drug targets follow in many medicinal chemistry laboratories. Synthesis of potential drug compounds and verification of their purity and structural identity primarily using mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Optimization of conditions for a biochemical assay and verification of its reproducibility. Use of an optimized assay to measure the potency of potential drug compounds to achieve a desired biochemical effect. Application of structure-activity relationships to propose new chemical structures that might show further improvements in potency. Best practices in laboratory safety, chemical hygiene, note-keeping, and professional report-writing. Senior standing.
Pathways: N/A
Course Hours: 2 credits
Corequisites: N/A
Crosslist: N/A
Repeatability: N/A
Sections Taught: 4
Average GPA: 3.61 (A-)
Strict A Rate (No A-) : 41.92%
Average Withdrawal Rate: 0.00%
| Andrew N Lowell | 2024 | 70.8% | 26.4% | 2.8% | 0.0% | 0.0% | 0.0% | 3.61 | 4 |